I've killed lots of coyotes in north Mississippi, most of them with .22 LR using both rifle and pistol. Never had a problem putting them down.

Unfortunately, I've had to kill a few dogs too and only when absolutely necessary. A couple of big aggressive curs I put down with a .40 and it stopped them quickly. Another I shot with a .357 and it was DRT. Just me, but a .380 wouldn't be my go to aggressive dog round.

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