I'm novice shooter, but I took my recently purchased 642 to the range yesterday and I went through 20 Speer Gold Dots and 20 Remington Hydra-Shok loads (both are +P).

I found the Gold Dots had a bit more recoil and were a bit harder to group for accuracy. The Remingtons felt better and were more accurate for me. I decided I will be buying the Remingtons from now on.