Thanks guys for the replies....all good suggestions. I do like Unique as I use it in my .44 Specials and Magnums, the .45 ACP and the AR as well. So I'll surely give it a try in the .45 Colt. I also like 2400 in my .44's as it is about my favorite powder. I'll, for sure, try it too. Hogdon's powders are good too, and I completely forgot I do have a copy of that cowboy manual. thanks 2000Z-71