Lately, I've been lazy and let the big guns ride in a bag in the truck. I have a M625 .45 ACP Mountain Gun and a Browning Hi-Power, and extra ammo, at my feet when I travel.
In my pocket is a Colt Agent .38 special, loaded with NyClads.
Out on the farm, it can be most anything-USFA .44 Special SAA, Colt PPS in either .38 special or .32-20, S&W 2nd Model HE .44 Special cut to 3 1/2", or whatever I dig out of he safe.
It's nice having choices.