I assume you are concerned about full penetration in a self defense scenario. You can experience this situation with any ammo. No loading is guaranteed to only penetrate a set distance. Target mediums, clothing, shot angle, shot placement and many other factors make this impossible to predict. One of the best known penetrators is the 124 gr 9mm loading which is ballistically inferior to the 125 gr 357 mag load. The flips side of this is of course, insufficient penetration. Also bad.