No. Choose something bigger.
Well... I finally decided to comment in this thread as I have what may be an uncommon situation. I have had 8 surgeries in 3 years (#8 is tomorrow morning), and I am being medically limited to shooting 22 only. No 22 magnum, just Short, Long, and Long Rifle. For me, it was either accept that choice, or be restricted to nothing at all. I am taking the first option. Some of my nerve damage will be permanent, and I'm not sure when the use of a larger caliber will be possible.
Because of this, I have acquired several 22 firearms, rifle and pistol. I understand the limitations of using a 22 for self defense, and for concealed carry, yet I will honor the restrictions my doctor has given me.
Currently, I have a Kimber Rimfire Target, which has been nearly flawless, but it's full size and something I would likely not concealed carry on a regular basis.
However... a Browning 1911-22 (A1, Desert Tan, Composite frame) is in my future! This is 85% the size of a regular 1911, and operates the same. I'm thinking this would be a great carry firearm until my restriction is lifted.
Ammunition choices present a dilemma. I have a large variety of ammo to choose from, and hope to test several types for reliability and accuracy. Common recommendations seem to be CCI - MiniMags & Velocitors, with some recommending the Aguila 60g SSS. I have tested all of these with my other 22s and every one performs perfectly. Not a single malfunction with any of these.
If anyone has other ammunition recommendations, I would appreciate it.
Suggesting a larger caliber is not an option right now. My options (from the doctor) are 22 or nothing. So I am choosing a 22.
Thanks to everyone for the advice!