Sir;
I also have a 250 but have been carrying it in a leather holster. I have used the Serpa's for M9s (Beretta 92 FS) and the M11 (SigSauer P228). I don't recall what the finish was on the M11s, but will say after a year of carrying there will be some standard holster wear. I don't think that it is going to damage the Nitron finish on the 250 to the point that it will degrade the protection, but as with all of the "plastic holsters" there is going to be some type. I know that isn't a scientific answer...but the government didn't train me to be a scientist