The safety on the PP, PPK and PPK/S all work the same as the Beretta 92 and S&Ws. Push it down and the safety is on, and if the hammer was cocked it decocks. Push it up/forward and the safety is off. I load mine, chamber a round, then holding the hammer with my right thumb, work the safety with my left hand, lowering the hammer with my right thumb (I don't trust hammer-drops). Once the hammer is down I take the safety off. Carry it hammer down on a live round, and if I need to shoot it I just draw it and pull the trigger, like it was a K frame.
As small as it is, the fleshy part of the V of my hand tends to ride a little high, and the bottom of the cocking-serrations on the slide slice my hand, like a saw. Once I realized what was doing it, I took a dremel to the bottom of the right side of my slide, and relieved it a little. This "Walther bite" seems to be common. Since you are left handed, it if cuts you it will be the left side of the slide. I guess it depends on how big/fat your hand is.
That's the only problem I've ever had with any of the ones I've owned (PP, two PPKs and a PPK/S). And it was just the PPKs that bit me. The longer grip of the PP and PPK/S kept the slide off my hand.