I've taken lots of deer with .44 Magnum handguns. My latest, which is now a couple of decades old, is my hand's down favorite . . . a 6" Model 29-5 with the "Endurance" package that's now standard.
After shooting lots of deer, I've abandoned the fast 200 grain, and yes, even the 240 grain Hollow Points.
Since switching to flat nose, hard-cast lead bullets everything I've shot for years has gone straight down . . . or not run far. Those that run have massive blood trails, for a heavy, flat nosed bullet blows right through with massive knock-down power too.
No more lost deer . . . like one shot with my old Thompson Contender and a 240 grain Hornaday XTP hollow point in 1998. Distance? Right below my stand . . . maybe ten feet! Another hunter on our club harvested that fat doe in a foot plot two weeks later and didn't know it had been shot . . . until my XTP bullet fell on the ground when he skinned it out! It hit bone immediately, mushroomed harmlessly and didn't penetrate at all. A real weird thing to see indeed.
Nope, make mine a hard-cast Keith style bullet running fast. It will blow through a deer end-to-end they say, at 500 yards.
I'm decidedly partial to the fast Federal "Castcore" 300 grain hunting ammo (shown below). Supremely accurate . . . totally reliable and effective.
T.