I hate to run across this product when I'm working on guns. When someone uses the strong stuff, I run the chance of stripping screws or breaking stuff. S&W doesn't use this on their guns because they know how to tighten them down correctly. They have been making revolvers for over 150 years, so I'd take their opinions on some stuff. I paid good money for the S&W Armorers manual plus the AGI DVDs so I'm prejudiced on some gun repair methods. Schools can do that to a person.
I promise you, If I ever worked on your gun, your extractor rod wouldn't loosen up, and I didn't use 1 drop of locktite on it.
Sure, the other minor screws will loosen, but that's what a screw driver is for. Whenever I clean them, I go over the frame and just snug all the screws up. Shooting the 500 Mag, you really need a screw driver and go over that gun!
I love guys who locktite the rear sights on their pistols then cry that the gun won't fire. The stuff leaked down into the firing pin channel and froze the firing pin up. Into the oven it goes!

But that's another story.