I have the 22A with the 5.5 barrel. Bought it used and extremely dirty. Still shot well but failed to feed 5 of 200 rounds. Cleaned it well and it only failed once in the next 200 rounds. If you use standard cleaning it needs to be cleaned every 250-300 rounds. I found that using Frog lube...
I'm sure we over think this. I'm a 9mm guy as I feel today's ammo is more than capable of doing the job. Problem comes when you are not accurate with that 9mm. My GF for instance can't hit a full sized silhouette at 21ft with my P226 9mm but she can make 10 inch groups with my LCP in .380 and 5...