First, I can't imagine a reason, other than some awful fouling, that would cause me to remove a cylinder for cleaning.
Second, let me reiterate what a cowboy action shooter once told me, and I love to repeat this:
You should clean your guns in February. if you forget, there's always next February.
Third, I admit to being a fastidious, gun cleaning nut back in the day. As I got older I got lazier - and my guns shoot to point of aim, zero, MOA, whatever, whether I cleaned them or not. The only gun I have ever had an issue with that I hadn't cleaned after HARD USE was a Navy Arms/Rossi Model 1892 lever rifle - the spring in the tube magazine got fouled up and rounds got stuck once.
Cleaning guns is not rocket science but I recall a line from an Old Western when a gunman was accused of shooting someone and then cleaning his guns to cover it up - "My guns are always clean". Back that refers to blackpowder - if you didn't clean those you could easily get into trouble.
I'll go so far as to note that cleaning pistols is somewhat more of an obligation, too, because a dirty slide can be an issue. Otherwise, I have no guilt if I shoot some guns and put them up without cleaning them. I never put them up hot, but clean is a whole nuthuh smoke (pun intended) and I don't worry about it like I used to.
One issue - a carried gun, one from a pocket, or a purse, or even left around (some of us do that), will pick up a lot of lint and dirt that you MUST clean more regularly.
YMMV, of course, and I accept anyone's criticism that I'm underserving to own firearms. I have many dozens and none are angry with me but some of my colleagues get that way and I understand.
***GRJ***