I'd suggest reduced loads for the Speer 325gr 50AE bullet. I don't see a suggested velocity range for them, like Hornady has, but since the 50AE only has a max pressure of 35K PSI, logically it's not designed for 50K+ PSI loadings. I don't know anything about the IMI bullets but I think forum member Colt SAA loads them so maybe he can comment on them.
I use Hornady's taper crimp die (#44702) when I load Berry's plated 350gr RNFP bullet. It has a cannelure but it's close to the base & when seated to it you don't have enough bullet-case tension (plus their bullets are poorly sized) to hold it, & avoid bullet jump, so I seat them deeper & taper crimp them, which helps some. They're rated by Berry's to 2000fps but I only use them for reduced load at indoor range distances.
Reduced loads with moderate powders are often criticized but if you use extra care & a single stage press where you can verify the powder dispensed each time, you should be good. I use Unique, LongShot, Bluedot & 2400 in some of my reduced loads.
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