Submitted for some friendly discussion.
[I think the best N frame is one in 44 Mag...]

But for this discussion let us consider the N frame's in "45".

Now I can see if a person is a Colt SAA 45 Colt shooter, he would want a S&W in 45 Colt...

Likewise if a person is a semi auto 45 ACP shooter he would want a S&W in 45 ACP.
I fit into this catagory. I bought a Mod 25-2 in the early 1970's because I was a Bullseye shooter, and it would shoot the same 45 ACP ammo, and I could use it in Bullseye matches too. [My first 2 S&W revolvers were 44 mags].

I also used a Mod 25 in 45 ACP as a Duty gun for several years, first with half moon clips and later with full moon clips when they became available.

I now have a 325NG, and I really like it.
I am a BIG fan of a S&W revolver in 45 ACP. BIG FAN.

So here is my question, IF you do not shoot 45 Colt Single Action Army's, and you are not a 1911 shooter in 45 ACP, which S&W in "45" would you pick, and why???