By what you are describing, sounds like the screw is stripped. You can use something to push the screw from the back side, while unscrewing to get the screw out.
Then try a new screw (call S&W) to see if the threads in the frame will hold, or if they are stripped/damaged. If the frame threads are damaged, you'd have to have it re-tapped. If so, I'm sure S&W will take it back under warranty. Good luck.
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