One of my favorite revolvers is a Redhawk converted to a .50 Bowen Special. It is a proprietary cartridge from Bowen Arms and is essentially a .500 Linbaugh shortened to the length of a .38 special cartridge. Unlike other .500's, this is designed to be (and is) a very pleasant round to shoot. When I used to hunt, it cleanly took wild boar and black bear with full penetration. This from a 350gr WFN cast bullet at 950fps. For fun, I load it down to 750-800fps.
For hunting, it's really the best example I can think of of why intense horsepower is not needed in large caliber heavy weight bullets. Anyway, back on point and to answer the thread question. For me, yeah. It just depends on the .50.