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Thanks for your comment on this and advice. I'll probably keep an. Eye on it next time I take the cylinder back and the screw back without using anything. If it would ever go loose, I'll try the purple from then on.

Also, if you search for any yoke screw, every image I see shows it with red locktite on it! (e.g. Smith & Wesson Yoke Screw Assembly S&W K L N Frame Blue)

I noticed my new S&W 686SSR already came with a tiny drop of loctite on the cylinder side plate screw when I unscrewed it to take out and clean the cylinder. It was red, definitely not blue or purple. Also, had to use quite some force to unscrew it. I put a tiny drop of Loctite back on it when...