I would suggest that if you have a way of getting to hear different cans on your gun that would be the best. Price wise silencer shop in TX has the best prices online and work with dealers all over the country. What state are you in? I am slightly prejudiced towards the Liberty Yukon TL, light , quiet, take apart, excellent technology, warranty , service, price. That said I also sell them. Some people will suggest Silencerco sparrow, or spectre II,, gem tech outback,liberty essence, Innovative arms Apex. There are others that I can not comment on since I have not used them. But I have compared the 6 above at the ( same time, temp,barometric pressure, location), using 15-22,10-22,marlin papoose, ruger MKIII, SW 2206. I used sub sonic cci + rem, standard vel, and fed and win HV ( 1250 fps) . The results were that subs were quieter than HV, standard were close to HV sound. ALL exhibited FRP at some time during testing, depending on time between shots and ammo, very variable. The liberty Yukon TL, on a 16" 15-22 with CCI quiet were the quietest, based on my ears and the 4 other people involved. You can pay more or less but you cannot get more quiet. If you consider an integral, Innovative arms firing Fed bulk HV is the quietest of any and all. You only hear the action noise, check out their video, I would make a video but I could not do it better, I have been shooting mine nearly 1.5-2 yrs and cleaning is simple. All of the above are rated for 22 lr, 22 mag, 17's and a few others. You stated "multi caliber" not sure what you mean, you do not use a centerfire can that you can not take apart with "dirty"22 lr. Be Safe,