There are some lowers made of plastic that are not the 22lr. Plum Crazy, and Vulcan/ Heese. Pass on them. Too many issues, and the cost saving is minimal at best.
I will give you a little schooling on alloys (Aloominium!!

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There are uppers, and lowers made of 6061, and 7075. FWIW, 7075 IS STRONGER. The strength runs near the 70,000 psi range for tensile strength. 6061 is in general near the 60k mark. Lots of grades of aluminums. As in: 6061 T6. The T6 is the age hardening on the aluminum. A T65 is hard, but has some different qualities that make it more formable; ie bendable. It will work harden, meaning as you bend it (Work it) it will stiffen and then SET in the place you bend it. If you try to bend it substantially more, or try to bend it back? It's going to crack.
Machinists like 6061, as it is easily worked, has good weather resistance as well as chemical resistance, and it is EASILY WELDED. This becomes a big plus to certain gun builders who are looking to experiment and radically alter and customize their rifle parts.
7075 is very durable; it's about the strongest aluminum made. It is usually a cast material. It has great properties for wear resistance, and as such, it is very much preferred for moving mechanism housings. (Rifle parts qualify as such.) 7075 is more rigid, and resists bending and flexing much better than cast 6061. It also has great weather and chemical resistance.
The one drawback to 7075 is that due to its' hardness, it does NOT like to be welded. Billet, extruded 7075 is grumpy stuff to weld. And, it cracks more than Whitney Houston partying with Charlie Sheen!

Cast 7075 CAN be welded, but it is usually a specialist who would do this, and I will say, it will NOT be a structural weld, so do not stress that part.
For say a rifle lower, yes you could get away with welding up a cracked magwell (Ask me how I know!)

But it will always be less than it was. I have welded a lot of aluminum in my time, and the worst project is trying to graft unknown aluminums together, ie 6061 and 7075. The materials fight each other usually, and the weld fails.
Now, with all this said: If you were to be experimenting with side charging, or belt feeding experiments, then I would say get 6061 parts to work with. Once you perfect it, a 7075 unit would be stronger in the long run UNLESS you had to add material to create a port, mount plate, lock or release type of mechanism. Or, if you had to add beef to make it hold more pressure. (This last scenario requires a very experienced welder who is rather meticulous in prep work, lest you see a weld fail at the most inopportune time.)
For box stock lowers, both are fine. For uppers, 7075 is preferred because of superior wear resistance.