I'm shooting 15.0 grs 2400, WW STD primer, and a commercial cast 158 gr SWC (no gas check), in my 6" 586-0. No leading. This load is listed and used by many shooters.
While the Speer manual 14 doesn't go quite this high a charge, it lists all 2400 loads with STD primers. Conversely all H110/WW296 loads are with Mag primers. The latter are spherical powders, and while 2400 kind of looks that way, it isn't. Ball powders are hard to ignite.
Down at 12-13.5 grs I did get leading, which seems to comfirm the status quo over at Castboolits.com that a slower powder at a higher velocity is your friend. Similar velocities with say Unique would be a different story, as the faster powder would "melt" the base of the bullet and or has some blow by and melt the sides, leading to leading, no pun intended.
Also, 2400 is signifcantly less expensive than H110/WW296. For example, Powder Valley, who has the best prices on powder, is $109.50 for 8 lbs of 2400, vs. 129.50 for 8 lbs of H110.
Powder Valley, Inc.
This load will only be even more happy with another 2" of bbl.