I have a 1911 Colt rebuilt by Clark Custom to shoot 45 Super back in the day. I shot 45 Super from it for a while then lost interest when I bought a 10mm. The CC 1911 has a ramped barrel and they recommended a 20# spring at that time. At that time I did reload for it.
Certainly the basic 3rd gen pistol is strong enough to handle the load if a 1911 will do so, Ace Hindman (assuming that he still runs Ace Custom) would probably tell you what the conversion steps would be, even if he no longer does the work.
Sprinco makes a guide rod package for S&W w/5” barrel
Sprinco USA -- Recoil Reducers You would have to ask them about your 4506 and specifically about 45 Super.
I have a Sprinco in my 1911 Kimber, 10mm while it does not and in fact cannot reduce recoil it certainly does buffer the last few mm of slide travel, consequently there is no slam. At the same time it does not accelerate the slide forward much avoiding a problem with stiff springs.
One problem is that there is very little load development done now for super, the loads around are all quite old, for that reason if for no other I would stick to the +p. You can safely push a 230 gr jacketed bullet at 1050-1100 fps at pressures in the +p category which seems plenty to me.
I don’t know who if anyone sells commercial ammunition for 45 Super, but I will bet it is expensive.