Howdy
Just so you know, 45 Schofields have a wider rim than 45 Colt. About .520 vs about .512 for 45 Colt. MOST revolvers chambered for 45 Colt will have no problem with the wider rims. My Colts do not. However the clearance is a little bit tighter with a Ruger Vaquero or Blackhawk, and I have two Vaqueros that needed a little bit of work with a file in order to accept Schofield rounds in one chamber each. The rounds would not seat all the way in one chamber on each cylinder.
I do not own a S&W chambered for 45 Colt, so I do not know if there is a clearance problem at the ejector star with the Schofiled round or not. However, since S&W invented the Schofield round, hopefully they kept that in mind with their 45 Colt Hand Ejectors.