I have loaded a couple hundred 45colt and 45acp rounds over the past two weeks, using 2400 (45colt) and Unique (both). I have noticed the poor metering charachteristic. I get about a .15 grain variation at most, so I am not pushing the charges to close to the max. to ensure I don't get a max or higher load. All of the advice and anecdotes have been very helpful. I'll have to pick up some W231 to try. The Unique is very sooty and produces a lot of smoke.
I found that 6.9gr of Unique behind a 255gr LRNFP .452 bullet in my 22-4 45acp gives me around 925fps with no signs of pressure and is still well below the 7.5gr load Elmer Keith used. Because I favor fixed sights, I am now leaning more toward the 22-4 than my 45colt 25-13 MG (especially since I get the same performance for roughly 2 grains less powder). With the load I mentioned, poi is at poa. I'll pick up some Blue Dot and W231 this weekend and give them a try thru the chrono when I get a chance.
By the way, I loaded some Ranger Rick 700gr bullets for my brother's 500s&w mag BFR, last weekend. At 1250 fps, they went thru just about anything we shot them at, and were accurate. The recoil was absolutely brutal. My brother loved them, but I'll stick with 45colt/45acp and some occasional 454casull. Just thought I'd mention the 700gr stuff as an example of extreme heavy weight bullets. Good for nothing unless you're hunting Grizzly or dangerous African game, neither of which seem to abound in Vermont. My brother is a recoil junky, while I like moderate, traditional cartridges that don't rely on high pressure/velocity.