I myself prefer IMR4227 over H110/W296 for my hunting loads because it is a tad less temperature sensitive, likes heavy bullets and long pipes.
+1 on IMR4227.
I have found it much easier to find good loads in a 17" 445 Encore than 110/296 which acts quite skittish.
I never really know when I am going to go over pressure with the ball powder or even where to start when there is no data.
A1680 has also given results all over the place. Very high ES and SD.
4227 acts much more linear, less temperamental, with lower SD.
I am willing to give up 100 fps to get a reliable safe load.
Maybe I am overly judgmental but I have given up on ball powder almost completely especially for revolver rounds even when shot in rifles.
In the 44 I consider the 200 grain bullets suitable for the Special, the 240 standard for the Magnum and the 260-275 perfect for the Supermag.
The 300's belong in the 444 if built well.
Translate this to the 45 as you will.
All of this can be done well with cast bullets IMHO.
Just use gas checks as you go supersonic.
My most accurate loads so far for the mag and supermag are both WFNGC slightly under max pressure.
Big Bores don't really need an expanding bullet for awesome performance.
The big meplat of the WFN takes care of that.
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