Dirty Harry has some valid points but I still like my 4" M500. Much like the M29 did in the 70's with the .44 mag, the 500 does today.
What I'd prefer is a 16" SxS double in 500 caliber.
As I always say, simply wanting a firearm is the only reason any free man requires.
Also, unlike some folks, I'm not arrogant, so I won't go making brash statements about the choices of others either. Admittedly, the Model 500 is very cool gun which at one point I myself had my sights set on, but upon doing research into the .500 S&W Magnum cartridge I slowly lost interest. The Model 500 definitely lives up to its title as "The most powerful handgun in the world" and as such has obvious applications as a formidable cartridge for dealing with dangerous game, but for the size and weight required to accommodate such power while still generating some serious recoil which borders on unwieldy, it seems excessive. So for me personally, I would sooner opt for something less powerful yet easier to manage like a .44 Magnum or forgo a handgun entirely in favor of a long gun with equal or greater power which is easier to control.
Case in point, if I were going into Grizzly Country, then I would sooner pack my Mossberg 590 Shockwave loaded with Brenneke Black Magic Magnum Slugs. It's a bit bigger and heavier than a S&W Model 500 Revolver, but it's more powerful as well as easier to control.
If I were going to get an X-Frame Revolver, then it would be a Model 460XVR. Second only to the Model 500 in terms of power, but still more than enough for just about anything, but with the added utility and benefit of being able to chamber the less powerful .454 Cassul and .45 Long Colt, both of which still being powerful cartridges in their own right, with the .454 Cassul holding the title of "The most powerful handgun in the world" until the .500 S&W Magnum hit the scene and the .45 Long Colt holding the title from 1873 up until the invention of the original .357 Magnum.
Still, the .500 S&W Magnum is without a doubt a powerhouse that only a total fool or an overcompensating wuss would ever attempt to argue didn't have its uses.