Yes. The 4506-1's trigger is better in DA than my 645. The only two things I've been debating changing on my 645 are the trigger and having the trigger guard/front strap relieved.
Novaks in Parkersburg WV does both mods on 2nd generation S&W's.
There was a member here who knew a great deal about 645s. He had 78,000 rounds through one of his 645's. IIRC he stated that the late production 645's - the ones right before the transition model 6451, 6452 and 6453 - had a different trigger geometry.....possibly a different drawbar too.......I can't recall....but he said that if you sent your early 645 into S&W they would modify it with the later trigger - which greatly shortened the DA pull.
I'm going on my not so great memory here, and it was several years ago, so take what I've told you with a shaker of salt.
While my 645s DA pull is very long, it is very smooth. I don't consider it a handicap - in fact, I consider the long smooth DA pull an asset on a duty pistol. The SA pull is as short and crisp as my Colt 1911s.
The 4506-1's I own have shorter smooth DA pulls. I can shoot them slightly faster out of a holster.....thats about the only difference. I can't see any difference in accuracy between the 645 and the 4506/4506-1. Mine are all tack driving accurate.
In fact, being an old revolver guy I will say that my 645/4506/4506-1's are as accurate as my model 19/66 revolvers. At 10 yards I can print 5 round cloverleafs on the quater size Shoot-N-See bullet hole patches with my 4" 66-2. I can do the same with my 645 and 4506's.......except the Shoot-N-See gets blown away and there is just a quater sized hole left in the paper.
The slide I currently have on my 645 is a late production transition slide I purchased from a very kind member here. I think it is from a 6452 or 6453. It has factory installed Novak low mount three dot sights on it. Looks great on the pistol, to me.

Regards 18DAI.