Kevin; First I have a 22-4, and its a sweet shooter, and never any trouble with the lock.
I use 6.5 Unique, with 230 gr lead sized .452, and gun is "right" on with original sight blade. Only change was a pair of nice N frame diamond magnas, to make the gun appear, circa 1950.
As far as the "2400" loads, I have experimented with them.
Lyman Reloader Manual #3, a 1959 book, had "2400" load data for the .45 Auto Rim, using "FOLDED HEAD" or BALLOON TYPE R-P cases(yes, the earliest 1920's A-R's by Peters were folded head, as I have some).
The data STARTS "ABOVE" the 13.5 grs. you mentioned. Bullet weights were 240 and 255.
The MOST "2400" I was able to get in the SOLID headed case, and still seat the .452 sized 250 gr. hard cast swc was 15.0.
I used a nearly mint M-1955 Target (M-25-2). First, accuracy was great-BUT; 1)FELT recoil was like shooting an M-29 with nearly full house 245 gr. .44 Mag loads. 2) Leading after only 6 rounds, was horrible(gun was clean before this!)
So after this experiment, I discontinued the loadings, recalling that Elmer Keith was never really too keen on "2400" in .45 acp. His preferred load>IIRC. was about 7.3 Unique with a 230-240 grainer.
Velocities in the "old" Lyman Manual, were 1119 fps. for the top 2400 load, and Keith
s loading with Unique, ran a tad over 900 fps.
Of course bbl. length was 6.5" on the M-25-2 "test gun".
I think this is THE ONLY refernce I have to using "2400" in .45 acp/.45 A.R., and the "old" manual warns about using caution with ANY "2400" loading in this ctg.
Hope this helps a bit
Bud