I shoot almost exclusively lead bullets in my 66s, 686s and 629s for punching paper.
In .38 Special cases, I prefer hollow-base wadcutters and the only brand I can find right now is Hornady. The bullseye boys still regard Remington HBWCs as the most accurate but they are on back-order until November everywhere. The Hornady dry lube is messy on the hands if you handle a lot of them (I loaded 250 yesterday) but leading is minimal and they are accurate enough. In .357 cases, I load Precision Cast 158-grain LSWCs and they are much cleaner to handle as are the .240-grain LSWCs of the same brand that I use in my .44s.
I load the wadcutters to 700fps, the 158 LSWCs to about 800fps and the .44s to 900. I have one 686 that will accumulate a little lead just forward of the forcing cone but it cleans right out.
I used to load jacketed bullets but for the few rounds shot while hunting, it's just easier to use factory fodder. I use Hornady ammo in both the .357s and the .44s because their XTP bullets are considered the class of the handgun hunting bullet field right now.
Being a recent returnee to handgun shooting, I initially used the powders that were popular 35 years ago, Bullseye and Unique. I quickly found that by today's powder cleanliness standards, both are filthy-burning and Unique gave me erratic chronograph readings in the .44 and .45ACP. In a quest to find one powder that will work in .38, .357, .44 and .45ACP target loads, I settled on Hodgdon's Universal and so far, so good.
Ed