At a gunshow some years back, a man had a blown apart S&W on display on his table. The top strap had let go at the rear and was grotesquely folded up over the barrel. The cylinder had a completely blown out chamber. IIRC, the outer walls of the adjacent chambers had peeled back as well. I stopped to ask him about it.
Turns out, it was a S&W in .45 Colt. He had loaded up some Ruger-Only loads for a Ruger he had, and somehow, some way, one of these cartridges made its way into the S&W. The result was on display as a warning to all.
I know some will say he was just careless and that could not happen to them. Personally, I would rather not have cartridges around that could change one of my guns into a hand grenade.