I second what bwienert has posted about loading per Brian Pearce's articles from Handloader. One classic load for the 45 Colt even in post-WWII Colt SAAs is 20.0gr 4227 and a 250gr LSWC. This can be safely upped to an RCBS 45-270SAA bullet weighing in at about 282 gr. In my 25-13 Mountain Gun, this chronos at 945fps. In my 625-6, not a Mountain Gun but one of the Performance Center 6" weighted slab barrel versions, it does 973fps. The later gun has fired up to about a thousand rounds of this load, it still maintains <2" accuracy [with a Holosight) at 50 yards and is as tight as ever. It is a bit of a specially made gun though and has a front locking detent. You can go "a tad" higher on the 4227 but know what you are doing. For the most part the gain is only marginal and not really necessary for field situations. These guns can easily and consistently handle 23Kpsi loads, same as the 45ACP+P. No need to push it for small gain.
I haven't tried 300s in either, not really seeing the need since the 270SAA is such a great performer. The 270SAA is such a good load that I even use it in my Rugers, having long since found out that the heavier Ruger loads just aren't necessary to work any better. I also use a load that will push jacketed 250s over 1000fps based on Blue Dot. Although Unique works for some of these loads, I really don't like it for applications up that high, too erratic but, hey, some folks don't like Blue Dot either. Power Pistol and HS6 are good alternatives.
In addition to Linebaughs articles on it, every handloader who loads 45 Colt owes it to him or herself to get the June 2002 issue of Handloader solely for the article "Understanding the 45 Colt" by Pearce. There have been many mentions of loads that are good in subsequent issues, but this lays the foundation. He always lays out a very sound approach to such loads and has testing to back him up.