I've been carrying a S&W M60 or M36, 1/78", round butt J frame, 24/7 for over five years now.
Regularly, I used a Bianchi "Pocket Change" holster for right front pocket carry.
To reduce to over all size, I use Pachmeyer Compact Professional grips. The grips illustrated above in the holster photo are also Pachmeyer's but this style with the finger grooves actually adds bulk. I had some like them and they were too big, I gave them away. The ones below are the way to go.
This system has worked great for me. I've tried Uncle Mike pocket holsters, but they just don't have the stiffness to work effectively.
During the winter, on some occasions, I use a Bianchi shoulder rig, and this is only used when wearing a sweat shirt, hoodie, jacket, etc. I find this shoulder rig very comfortable, but you just have to have on quite a bit of clothes to hide it.
This is a model 4620 holster can comes with an "X" configuration harness with the speedloader poaches on the opposite side. I also another harness for it that is over the shoulder, and behind the back. The "X" holds it very well. In this rig the gun is held horizantaly , but I have no problem with this, since it is a double action revolver. I would not carry most semi autos that way.