Otterbein,
Now there is a name from my past! Only it that one wasn't from Ohio, he was from Oklahoma. We met in Iwakuni Japan, a long, long, time ago!
At any rate, for less flash faster powders are better BUT velocity suffers. I know folks that are shooting Unique out of their 2" barreled guns with the FBI load that develops close to 800fps. Not me, I'm the one reloader that has no use for Unique!
SR4756 is ALWAYS a good choice for 38spl +P loads and it meters TONS better than Unique. HS-6 is used by our very own Archangel, and I'm sure he will show up soon to tell us all about it! (I think he gets paid to advertise for them!

) It meters like a dream too. Herco, just a tad slower than Unique and much better at metering, is an unsung hero in these applications as well. 2400 is going to give you good velocity but you already know about muzzle flash.
I, and this is just personal preference, would stay away from hot loads with Clays. The pressure curve is CRAZY when you have a slight overload.
There is data out there for those kinds of loads. Maybe Erich will drop by and share his knowledge in this area too. He has a bunch of experience in this area.