I have a 325 Night Guard.
First, let me say I used S&W Mod 25's in 45 ACP for seveal years ad a duty gun. First with half moon clips, and later when full moon clips became avialable I started using them.
So I like the full moon clip system, and I like the concept of an N frame S&W in 45 ACP...
Now to the 325 Night Guard. It is a Scandium frame gun, ie a lightweight frame.
So you might not want to shoot in thousands and thousands of rounds...
However for normal non high volume competition use, I do not worry. I have some 5 shot S&W's that I have had since 1972 that have been shot a bunch, with hot duty loads, the still work just fine.
So. with the above experiences and qualifications, I find the S&W 325 to be a Most Excellent handgun. I keep mine under my pillow EVERY night.
I take it on a lot of road trips. I have a holster specially designed as an anti carjacker holster. It is made in South Africa.
While it is not as "handy" in my pants pocket as my S&W Bodyguard, I do have some pants where I can carry the 325 in comfort and concealed.
Many times I do so...
I find it very controlable with full power 230gr 45ACP ammo, and controlable with +P 45 ACP as well, although I do not see the need to shoot +P in a short barrel.
It has become one of my favorite revolvers.