You did not mention, but I assume you are writing about a 2" Safety Hammerless? If so, most 2" Safety revolvers were manufactured post-1898, so are considered "modern" by the BATF. That also means they were built in the smokeless era. Some think that something magical happened to S&W models that were manufactured on and after January 1, 1899, and they all became stronger and ready for smokeless powder, but that is not at all the case. The 32 Safety Hammerless built either before or after 1899 is exactly the same gun, so current manufactured ammo will function just fine in either era guns.
As for old pocket revolvers other than S&W, if the barrel is stamped with the caliber name, I would shoot it today. The only calibers that changed physical dimensions over time still manufactured today were those that started out with heeled bullets and later transitioned to seated bullets. Even those calibers can be shot today with current ammo since the bullet is actually smaller than the bore.
One thing I will say is that there were some really cheaply made pocket revolver and they are typically from lesser known brand names. On the other hand, H&R, Iver Johnson, and other known brands were built with sufficient strength to fire modern ammo since major manufacturers designed their current ammunition to be safe to shoot in top-break revolver and loaded light with low velocities and pressures. Almost every old pocket revolver still out there have been shot with smokeless ammo over their lifetime and survived to this day. The biggest issue shooting these is that they can break just like modern firearms, but parts are almost non-existent today and if you break springs, chip sears, or the gun just quits working correctly, you have ruined any value it had, so go easy at the range with these vintage classics,