Please explain how the manner in which a gun is held can affect the internal workings of the gun.
It's an excellent question and I will try to answer it.
As Bob O pointed out, there is the phenomena of "limp wristing" the gun. This is not necessarily as straight forward as it might seem by the term. There are a few things going on.
All semi-auto pistols are designed to work with the recoil produced by firing the cartridge. There is a delicate balance between recoil spring strength, mass of the slide and the power of the load used. As the mass of the slide is reduced, i.e. the Shield, the power of the recoil spring must be increased. This is why small pistols are difficult to operate; strong springs.
If the motion of the slide is retarded, the ability of the slide to eject the spent round and chamber the next is reduced. Retard that motion enough and you have a Type II malfunction (stove pipe) or failure to feed. This reduction in slide performance can be caused by several factors, one of which is the shooter.
The proper grip will provide a relatively solid resistance to the rearward motion (recoil) of the gun under fire. Cushion that motion with a loose grip and it's possible for the shooter to induce a malfunction. I've seen it many times. Strengthen the grip and the problem goes away. Give them a different gun, with different operating characteristics, and the problem goes away.
The problem with changing guns is the shooter will often then blame the first gun. They'll say, "That gun did..." when in fact it was the shooter that caused it.
There are some guns that are more prone to shooting induced malfunctions than others. It has been my observation that the full size models of most handguns have far lower propensity to malfunction. This is likely due to the mass of the slide.