I've tried several, no help at all.
Last time I looked at them, I was told the problem was that I was buying the "cheap" ones.
If I really wanted it to work, I had to step up and pay (IIRC about $300) the price for a "good" one (which the person happened to be selling).
And, no, I didn't.
The OTC joint stuff, especially, for me, if it has MSM in it, seems to help somewhat.
I tried lots of Advil and it helped until I got Gastritis (thankfully no ulcer).
Now I take the OTC stuff and one Aleve in the morning with breakfast and one in the evening with supper.
I still hurt. Guess it's part of the price for growing old.
Bob