In the interest of full disclosure, I do not have a 645. I have two 745’s. (if that matters?)
The 645 was S&W’s first entry in to a .45 ACP handgun. The 645 evolved in to the 4506 pistol. The 645 is much loved by S&W 1-2-3rd Generation pistol fans. The 645 is a 2nd Gen pistol and was produced from 1984-1988. The single stack magazine had a metal floorplate and holds 8 rounds. More modern magazines came with a black plastic floorplate and they are in very good supply.
The 645 is a DA/SA pistol, and that means with the hammer down on a loaded chamber, a long pull of the double action trigger will cock and release the hammer much like a S&W revolver does. Each subsequent shot is single action, the hammer will fall from a short trigger pull.
The 645 has a manual decock lever, if the hammer is cocked and you lower the decock lever, the safety will block the hammer’s path to the firing pin and drop the hammer for you as well. In addition there is a passive firing pin lock, the firing pin is unable to move forward and is locked in the rearward position until the trigger is pressed which actuates a lever that unlocks the firing pin so that it is able to travel.
The 645 was offered with either a simple blade rear fixed sight or the adjustable rear sight with protective wings. The 645 was only offered in a full stainless steel finish.
The 645 also had some real 1980’s pop culture fame as it was featured in early seasons of TV’s Miami Vice.
In 1988 the 645 was retired with the introduction of the 3rd Generation Model 4506. The 3rd Gen’s most noticeable improvements included better sights, options for sights, and ergonomic improvements that generally made all the pistols feel a little more slim in the hands.