351PD
I have the 351PD. Great revolver. Fun to shoot, light weight, 7 shots, and you now have carry ammo made for them. I carry the 40 grain Speer gold dots. Trigger pull is a little heavy but ignition is perfect in mine and with the hi viz front sight and zero recoil, I can shoot fist size groups to point of aim as fast as I can pull the trigger at 7 yards. Also, I have a couple 5 star aluminum speed loaders they make specifically for the 351 that work perfectly. Very good quality.
Check out the you tube video of comparitive ballistic tests between the .380 hollow point and .22 mag Speer gold dot. It will help put your mind at ease if necessary about carrying .22 mag for self defense. While not best option on any given day, if .380 is a valid option then so is .22 mag.
Lastly, as much as I like the 351PD, I am not a fan of the 351C. Extraction is an issue with the C, not at all with the 351PD, you don't get hi viz sight in the C, and the trigger pull is heavier or at least feels it. I pocket carry the PD all the time and with the thumb over hammer technique there is no problem with snag, so it really negates any advantage over the hammerless feature on the C.
Go with a 351PD. It's one of the best CCW options in the market today IMO.