I put Crimson Trace grips on a couple of revolvers, but not (so far) on pistols. It is not easy to put tritium night sights on revolvers, so the laser is a valuable asset for a self defense or home defense weapon.
It is important to practice with iron sights. There's no substitute for that competency (batteries fail, lasers fall off). However my group size is cut in half using the laser. I can keep all my shots inside the black of a 50' slow fire target (3"), at rapid fire rates. On paper is good enough for SD.
For a pistol, I would suggest laser grips, or a rail-mounted (or trigger guard mounted) device with a grip switch. I wouldn't mess with the action using a guide rod laser or such. The offset doesn't matter for SD. If your sights are okay, line up the laser at 50' or more to avoid parallax errors and you're good to go. That done, I have not yet had to tune the aiming on the range.