As I got more centerfire rifles I found that there are hundreds of 22 caliber weights and brands of bullets. With the exception of this Savage rifle (75 grain Berger VLD) and all my 22 Hornets, I use 50 grain Poly tipped bullets. There are 4 major brands: Hornady V-Max, Sierra Blitzking, Nosler Ballistic Tip, & Combined Technologies Ballistic tip. When I'm working a load from scratch, I start with the bullet I have the most of on the shelf, The powder that has a good reputation and I touch the lands with COAL then 25/1000ths off the lands. when I have wrung this to the tightest group I load 5 rounds of that powder charge and seating depth for each of the other three bullet brands. Of the 4 brands one will outshoot the other three. In my AR it is V-Max, in my Cooper 22 it is Sierra Blitzking In my 221 Fireball Contender it is Combined Technoligies, In my Weatherby 22-250 is was Nosler BT and my Custom 22 BR it is Combined Tech. You get the Idea! A friend was the same way but with 60 grain for higher Ballistic Co-Efficient. When you have narrowed it to one weight of one type of bullet, then you can stockpile when there is a sale (if that ever happens again!) Not being a true competitor I like small groups, at longer distance, but my goal really is ONE HOLE VARMINTS!
Ivan