I had a set on my 625-8PC that I use for IDPA. I loved the way they fit my hand and the gun, but, even on a soft shooting round like .45 ACP (170 PF), they hurt after while. They are small and hard and impart almost all the recoil directly to the hand - there is no give to the grip. I'm probably just getting soft in my old age, but for game guns, or any gun that gets shot a lot, I think rubber is the way to go. I moved the VZ grips to a fun gun that doesn't get shot a lot.
JMHO / YMMV
Adios,
Pizza Bob