The high velocity 300 Blackout round is still short of performance compared many similar sized rounds. In fact, compared to the old 30-30 lever action round, the 7.62×39 AK round, or even the .223 68-77gr rounds, the 300 Blackout falls short from a ballistics and energy perspective.
My problem is that once you drop the bullet weight to gain enough powder to make the 300 Blackout supersonic/high-velocity so that it will actually cycle in your average AR-15, you gain nothing over the .223 round. In fact at the 300-yard mark your typical 68-77 gr .223 round will be delivering more energy than that 300-Blackout/Whisper round, and at the muzzle they are nearly identical.
The .223 has proven itself to be an excellent soft target stopper without overpenetration. On steel and thick-hided hogs, the Blackout seems like a winner, but in most other cases the 300 has shown to be a consistently and severely over-penetrating round. There is no way I would risk using the 300 Blackout for home defense. That is perfect for thick skinned hogs at close distances, but not so great for anything else unless you are shooting through barriers–but then again the 7.62×39 AK round is still a better option and far far less expensive.