Lots of good choices as mentioned. I'm in the process of testing most available defensive loads, and it's going to take awhile! But here are some of the favorites in 45 caliber.........
45 W-W Silvertips
Remington Plain Label 230 JHP
And the ever-popular (with good reason) Gold Dots!
As much as I like the Gold Dots they can be hard to find. In warmer weather with fewer clothing layers to penetrate I like the Critical Defense, in colder climes I think the W-W PDX stuff is
really good.
You pays your money and takes your chances.