Yes.
Results depend on the firearm used and basic ammo quality.
My testing is based on the use of single shot Hämmerli free pistols, model 152 electronic and model 160 mechanical, fired at 50 yds. Sorting club level Eley 22 ammo ($60-70 per 500) yielded results (10 shots under 1") close enough to Eley Tenex ($180-200 per 500) to make it worth the while. The rate of fire is so slow that the time spent isn't much of a bother.
The gun is capable of better, but you need a machine rest and indoor 50 yd tunnel.
Out of a Ruger Single Six or Harrington and Richardson, all bets are off! You're liable to find headspace variation chamber to chamber that equals or exceeds the variable in the ammo.
SSK (I think...) did make a tool to file the round nose of a 22 lr so as to resemble a SWC. Results were that it didn't hurt accuracy, at least out of hunting arms.
Rim thickness gauging is common practice amongst smallbore rifle match shooters. That's probably the direction I'd look if I wanted to get more info.
Best Regards,
Jim
PS: forgot to mention, easy way to "fake" machine rest test a free pistol is to clamp the barrel in a vise, using a split oak block to protect the metal. C clamp the whole thing to the bench. Easy to do on late Hämmerli FPs since you can remove the fore end.