I did a thread on these a while back on the M-P forum.
Warm weather here brings rattlesnakes out, at least in the lower elevations. I have yet to see any rattlers in Northern Arizona if I am in the backcountry over 4500 feet elevation.
I had my doubts if they would feed in my .45 Shield, and also wondered if they would have decent power and penetration compared to the bigger .44 Mag and .45 Colt shotshells I've used for years.
I needn't have worried, they feed fine. I started with one shotshell cha.mbered, and the next round, a JHP chambered fine.
Then I loaded two with the rest of the mag having JHPs.
Then I shot a full magazine of the CCI shells, they feed 100%.
They contain 120 grains of #8 shot, and the aluminum case has a bottleneck ( which probably helps the feeding) and a heavy roll crimp to hold the plastic overwad in.
I patterned them back a few weeks ago at 6 feet:

The plastic overwad alone would do some damage.
I shot a thick steel Progresso soup can and got both sides penetration with ease:

Today I got to use one on a rattler. I will leave them alone if I run into one on a rocky hillside, but one hanging around congested areas is not a good thing.
I parked in a dirt parking lot to take the dog swimming in a local creek, and when I came back this one was by my front bumper.
Several other cars had parked by me in the course of the morning, and I had seen several groups with dogs and small children go past on the trail.
I keep my own dog on a leash during warm weather as I don't want him to run up to a snake.
Trying to hit a moving snake with a solid projectile isn't easy, you could just as well miss or nick him and piss him off.
With these shotshells just point in the general vicinity.
After I shot he didn't even twitch or writh around like they usually do. DRT.
I didn't see any wounds in the neck but his head was devastated.

No guarantees they will feed in every .45 ACP, but they feed great in my .45 Shield.