Okay, I'd hate to sound like one of "those guys" but I'm going to go ahead and state the cliched but ultimately historically accurate opinion that in practically every configuration, the .45 ACP cartridge is effective.
Yes, "They all fall to .45 ball" is partially an Urban Legend referencing it's highly exaggerated and practically hyperbolic "Knockdown Power" but factually speaking, .45 ACP FMJ is indeed effective because it's a big chunk of lead with or without (in this case the latter) any expansion, and it has a tendency to expend most of it's energy inside of the target either way, reducing its potential for collateral damage compared to smaller, faster cartridges like .40 S&W and 9mm Luger.
That being said, obviously JHP is better, but considering the current ammo shortage, I think it's particularly worth mentioning that even with standard FMJ, .45 ACP has a reputation as a reliable man-stopper dating all the way back to 1911.
As far as what the "best" loads are for .45 ACP, it seems like anything over 185gr will perform reliably 100% of the time. Yes, there are some 185gr loads that perform reliably, but based on what I've seen, 185gr JHPs have a tendency to underpenetrate slightly, falling short of the FBI/IWBA's specifications by only penetrating to about 10"-11" in Ballistics Gel rather than the 12"-18" their specifications deem capable of reliable incapacitation. Besides, 185gr loads in .45 ACP seem pointless because although they feature higher velocity and energy than 200gr-230gr loads, they just don't penetrate as deeply or hit as hard, leaving you with what is essentially a poor-man's .40 S&W with a larger bullet and poorer ballistic coefficient.
So yeah, in my opinion, (which is worth what you paid for it or your money back) 200gr-230gr loads are the best.
In terms of brands/bullets, just about any name-brand .45 ACP JHPs will give you the performance you're looking for. In my opinion, Federal HSTs are the best, boasting both deep penetration and impressive expansion.