The Bisley grip on a Ruger crowds the knuckle of my middle finger against the trigger guard when I grip it. I don't think I have big hands, but the knuckle thing is a little annoying. I have the same problem with a Smith N-frame with grips that follow the grip frame outline. My knuckle rubs against the rear of the trigger guard. I have a Colt Mountain Gun (blued) with faux stag grips that is really nice looking, but if I want to shoot it I have to put the Ahernds back on. I guess I need a tyler t-grip if I want to keep the faux-stags. My brother said the revolver was so nice looking that I should have my knuckle surgically altered to fit the gun.
I don't have the knuckle-crowd issue with a standard grip frame on any Ruger single action. I'm currently selling my Ruger Bisley Convertible on line here due to the grip issue.
They are nice shooting guns, though. I was sorely tempted to buy a regular grip frame and trigger and swap it out for the bisley. Reall straight shooter, and easy on recoil. Purty, too.
Best of all, the 45acp/45colt thing is really nice. I was surprised by the accuracy of both rounds in the thing. I thought one would suffer due to the diameter differences, but it just wasn't the case. I guess what I'd really like is a 45colt/45acp Ruger Vaquero. But then I'd have to put down my Mountain Gun, and I just can't seem to get it out of my hand. I'm typing single handed at the moment. I'll have to get a 45acp Mountain Gun for the other hand. That'll solve the problem.