The only SA revolver I carry for defense is my NAA .22 LR Mini revolver, or my 4" Mini Master. ONLY because they are so small they allow me to carry when I can't carry anything else. The Mini Master has enough barrel to actually make .22 WMR viable for defense, but it's light, thin and compact so I can carry it IWB with shorts and aT-shirt on. The .22 LR Mini can be carried wearing pretty much anything, it's a Godsend when it's 95 degrees out and I'm wearing light gym shorts and a tank top. DeSantis and others make awesome pocket holsters for them, it's so light you can't even feel it. 5 rounds of Stingers beats fists if someone is trying to kill me. It's a "get off me " gun, not a gunfight gun. I also have a .22 Short mini but I think my fists would be a primary over a .22 Short lol
I'm so DA revolver oriented, and my muscle memory and training are so geared for DA revolvers that I would never make a larger SA revolver my "EDC", I'd be too afraid that in the rush of adrenaline and the "fog of combat" I'd pull that thing out and be trying to yank on the trigger of a Single Action revolver, I've actually trained myself NOT to cock the hammer and many of my carry revolvers are DAO..... so carrying SA revolvers is a recipe for disaster for me...no dice, I won't ever carry one except my "last ditch" NAA Minis,only because they don't make smaller guns than that and they don't come in DA.
If I were raised with SA revolvers and had been shoooting them since I was a toddler, then it may be a better choice. Lots of people are very skilled and muscle memory oriented with SA revolvers, so that it's second nature to them.
The disadvantage is that to get an SA revolver "ready" to defend yourself with, you have to cock it. A DA revolver is "ready to go" as soon as you draw it, but you still have the heavy DA pull as a safety.
I read a story about a small town police officer in Montana who carries a Ruger Vaquero as a duty gun, but we're probably talking a town where there might be 500 people and they just let him carry whatever he wants. He's no doubt an old timer who they just are letting him do what he wants until he's ready to hang it up. I don't see this flying anywhere but deep in a remote area like Montana, given todays litigous environment.