My choice would be the snub hands down. More reliable, more effective round and ECQ advantages as well. I understand the lure of the tiny auto, but I know I wouldn't feel too confident with a micro .380 if I was forced into stopping a determined attacker(s). The hammerless revolver, despite it's limited capacity, retains certain functional and tactical advantages in any scenario, but the same really cannot be said of the micro auto pistol since it's only truly positive attribute is ease of carry.
"The leading wound ballistic researcher in the world, Dr. Gary Roberts, recently weighed in on the issue in a wound ballistics briefing for the FBI. Here is his advice:
"Many small, easily concealed semi-automatic pistols which are recommended for law enforcement backup or concealed carry use fire .380 ACP or smaller bullets. While these small caliber handgun bullets can produce fatal wounds, they are less likely to produce the rapid incapacitation necessary in law enforcement or self-defense situations.
Handguns chambered in .380 ACP are small, compact, and generally easy to carry. Unfortunately, testing has shown that they offer inadequate performance for self-defense and for law enforcement use whether on duty as a back-up weapon or for off duty carry. The terminal performance of .380 ACP JHP's is often erratic, with inadequate penetration and inconsistent expansion being common problems, while .380 ACP FMJ's offer adequate penetration, but no expansion. All of the .380 ACP JHP loads we have tested, including CorBon, Hornady, Federal, Remington, Speer, and Winchester exhibited inconsistent, unacceptable terminal performance for law enforcement back-up and off duty self-defense use due to inadequate penetration or inadequate expansion. Stick with FMJ for .380 ACP or better yet, don't use it at all. The use of .380 ACP and smaller caliber weapons is really not acceptable for law enforcement use and most savvy agencies prohibit them. While both the .380 ACP and .38 spl can obviously be lethal; the .38 spl is more likely to incapacitate an attacker when used in a BUG role.
BUG–Infrequently used, but when needed, it must be 100% reliable because of the extreme emergency situation the user is dealing with. Generally secreted in pockets, ankle holsters, body armor holsters, etc… Often covered in lint, grime, and gunk. By their very nature, usually applied to the opponent in an up close and personal encounter, many times involving contact shots. A small .38 spl revolver is more reliable in these situations than a small .380 ACP pistol, especially with contact shots or if fired from a pocket."