There's two possible issues with cramming a full magazine into a firearm with the bolt/slide in battery.
The first possible issue is that the spring pressure on the top round is enough to make feeding a problem. VERY slight possibility that the extra drag on slide slows the slide enough that it's not moving fast enough to make a clean strip of the next round. There is a rebound effect from the bolt/slide hitting the buffer/frame. I do think this is the BHP issue, aided originally by a hump in the feed ramp. Not sure if it's magazine design or production tolerances, but being one down on the mag in the gun (with round in the chamber) is insurance that the mag will feed.
The second issue is that after being heavily compressed, there's enough drag from all the rounds in the box that the top round doesn't move into proper position and/or will no longer strip cleanly.
Finally, it's rare, but I've seen it: the bolt actually deforms the body of the top round.
My personal standard with the MSR family is that if I press down on the top round, I want the base of my thumb nail to be level with the top of the feed lips.
One year during our annual run & gun stress course we had some newbies loading mags for us. When I went to chamber a round, the gun locked up. Seems at least one was loading the P Mags until they couldn't take any more rounds. There was a short show & tell about magazine loading.